Chromatin and pluripotency: the MYSTerious connection.
basic_science · Level V
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- Record sourced from PubMed, PMID 22862937.
- Also identified by DOI 10.1016/j.stem.2012.07.013.
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Abstract
Although histone acetylation is critical for maintaining embryonic stem cell pluripotency, the molecular machinery involved remains poorly understood. Li et al. (2012) now show that Mof, a MYST family histone acetyltransferase, functions as a coactivator of Nanog-mediated transcription, maintains the expression of pluripotency-associated genes, and primes developmental genes for differentiation.