Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22862941.
- Also identified by DOI 10.1016/j.stem.2012.07.014.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
Medical subject headings
- HLA Antigens
- Histocompatibility Testing
- Induced Pluripotent Stem Cells
- Stem Cell Transplantation
- Tissue Donors