Exposing secrets of telomere-telomerase encounters.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22863000.
- Also identified by DOI 10.1016/j.cell.2012.07.015.
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Abstract
In order for telomeres to remain functional and stable, they must rendezvous with the enzyme telomerase in a productive manner. In human cells, this interaction is mediated by Cajal bodies as matchmaker, and now Zhong et al. reveal molecular determinants that establish good chemistry between the two partners.