Thinking outside the synapse: glycine at extrasynaptic NMDA receptors.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22863001.
- Also identified by DOI 10.1016/j.cell.2012.07.013.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue, Papouin et al. show that glycine is the endogenous coagonist for extrasynaptic NMDA receptors (NMDARs), unlike at synapses where the coagonist is d-serine. By enzymatically degrading endogenous glycine, they begin to address the enigmatic physiological and pathological roles for extrasynaptic NMDARs.