A mouse model to identify cooperating signaling pathways in cancer.
basic_science · Level V
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- Record sourced from PubMed, PMID 22863881.
- Also identified by DOI 10.1038/nmeth.2130.
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Abstract
We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis.
Medical subject headings
- Disease Models, Animal
- Lung Neoplasms
- Neoplasms, Experimental
- Oncogene Protein p21(ras)
- Signal Transduction