Highly conserved protective epitopes on influenza B viruses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22878502.
- Also identified by DOI 10.1126/science.1222908 and PMC identifier 3538841.
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Abstract
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8071 recognize distinct conserved epitopes in the head region of the influenza B hemagglutinin (HA), whereas CR9114 binds a conserved epitope in the HA stem and protects against lethal challenge with influenza A and B viruses. These antibodies may inform on development of monoclonal antibody-based treatments and a universal flu vaccine for all influenza A and B viruses.
Medical subject headings
- Antibodies, Monoclonal
- Hemagglutinin Glycoproteins, Influenza Virus
- Immunodominant Epitopes
- Influenza B virus
- Influenza Vaccines
- Orthomyxoviridae Infections