Nrf2 orchestrates fuel partitioning for cell proliferation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22883227.
- Also identified by DOI 10.1016/j.cmet.2012.07.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Why upregulation of the transcription factor Nrf2 increases tumor cell proliferation is unclear. Mitsuishi et al. (2012) now provide evidence that Nrf2 augments purine nucleotide synthesis, thus supporting tissue hypertrophy. This change in cellular metabolism requires loss of Nrf2 repression by Keap1 as well as costimulation via the PI3K-Akt pathway.