Fragmentation and unpredictability of early-life experience in mental disorders.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22885631.
- Also identified by DOI 10.1176/appi.ajp.2012.11091347 and PMC identifier 3483144.
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Abstract
Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.
Medical subject headings
- Anxiety
- Depression
- Maternal Behavior
- Stress, Psychological
- Uncertainty