Tomography and static-mechanical properties of adherent cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22886834.
- Also identified by DOI 10.1002/adma.201200492.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A tomography approach is used to reconstruct 3D cell shapes and, simultaneously, the shapes/positions of the nuclei within these cells. Subjecting the cells to well-defined microconfinements of various diameters allow for relating the steady-state shapes of cells to their static-mechanical properties. The observed shapes show striking regularities between different cell types and all fit to a model that takes into account the cell membrane, cortical actin, and the nucleus.
Medical subject headings
- Tomography