Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22886872.
- Also identified by DOI 10.1002/adma.201202296.
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Abstract
Two faced nanoparticles: A zwitterionic polymer-based nanoparticle with response to tumor acidity is developed for enhanced drug delivery to tumors. The nanoparticles are neutrally charged at physiological conditions and show prolonged circulation time; after leaking into tumor sites, in the acidic extracellular tumor environment (pH(e) ), nanoparticles are activated and become positively charged and are therefore efficiently taken up by tumor cells, leading to enhanced therapeutic effects in cancer treatment.
Medical subject headings
- Drug Carriers
- Nanoparticles
- Polymers