PI3-kinase and TGF-β in glomerular nephropathy: which comes first?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 22892855.
- Also identified by DOI 10.1038/ki.2012.154 and PMC identifier 3725284.
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Abstract
Transforming growth factor-β (TGF-β) and phosphatidylinositol-3-kinase (PI3 K) isoforms contribute to glomerular disease. Finer and colleagues define a temporal and selective role for the p110γ catalytic isoform of PI3 K, normally expressed by hematopoietic cells, and TGF-β in adriamycin-mediated glomerular injury. Early ectopic upregulation of p110γ by podocytes drives initial injury and proteinuria, whereas late upregulation of TGF-β drives fibrogenesis. Thus, proteinuria and renal fibrogenesis involve distinct signaling activated by p110γ and TGF-β, respectively.
Medical subject headings
- Class I Phosphatidylinositol 3-Kinases
- Doxorubicin
- Glomerulosclerosis, Focal Segmental
- Kidney
- Proteinuria
- Signal Transduction
- Smad3 Protein