Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22896692.
- Also identified by DOI 10.1158/1078-0432.CCR-12-0315 and PMC identifier 3422771.
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Abstract
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
Medical subject headings
- Pancreatic Neoplasms