Hippo signaling goes long range.
basic_science · Level V
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- Record sourced from PubMed, PMID 22901800.
- Also identified by DOI 10.1016/j.cell.2012.07.020.
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Abstract
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.