Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22902059.
- Also identified by DOI 10.1016/j.biomaterials.2012.08.006.
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Abstract
Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans, while displaying minimal hemolysis (HC(50)/MIC values over 3000) and a very high therapeutic index of 37 for killing S. aureus under inflammatory conditions in vivo.
Medical subject headings
- Anti-Infective Agents
- Imidazoles