Autonomous screening of C. elegans identifies genes implicated in synaptogenesis.
basic_science · Level V
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- Record sourced from PubMed, PMID 22902935.
- Also identified by DOI 10.1038/nmeth.2141 and PMC identifier 3530956.
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Abstract
Morphometric studies in multicellular organisms are generally performed manually because of the complexity of multidimensional features and lack of appropriate tools for handling these organisms. Here we present an integrated system that identifies and sorts Caenorhabditis elegans mutants with altered subcellular traits in real time without human intervention. We performed self-directed screens 100 times faster than manual screens and identified both genes and phenotypic classes involved in synapse formation.
Medical subject headings
- Caenorhabditis elegans
- Neurogenesis
- Synapses