Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.
review · Level V
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- Record sourced from PubMed, PMID 22908297.
- Also identified by DOI 10.1073/pnas.1207726109 and PMC identifier 3443177.
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Abstract
We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance effects are hypothesized to result from stoichiometric differences among members of macromolecular complexes, the interactome, and signaling pathways. The implications of gene balance are discussed.
Medical subject headings
- Chromosomes
- Evolution, Molecular
- Gene Dosage
- Genome
- Models, Genetic
- Phenotype
- Ploidies