A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22909278.
- Also identified by DOI 10.3109/14653249.2012.718887.
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Abstract
A recent publication by Phinney and his associates (1) has presented a discovery for which the field of cell biology has been waiting for more than half a century: a protocol that makes it possible to expand mouse cells in culture without the cells spontaneously transforming. Amazing though it seems, the secret is simply to grow the cells under hypoxic conditions.
Medical subject headings
- Cell Culture Techniques
- Cell Hypoxia
- Cell Proliferation
- Oxygen
- Tumor Suppressor Protein p53