Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 22914834.
- Also identified by PMC identifier 3430708.
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Abstract
To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene. In this observational study, 60 consecutive healthy first-degree relatives (aged 50.9 ± 6.2 years; 48% male; 30 G2019S carriers) were assessed using a computerized cognitive program, the Montreal Cognitive Assessment questionnaire, the Unified Parkinson's Disease Rating Scale Part III, and the Geriatric Depression Scale. G2019S carriers scored significantly lower on the computerized executive function index (p = 0.04) and on specific executive function tasks (Stroop test, p = 0.007). Carrying the LRRK2 G2019S mutation was associated with lower executive performance in a population at risk for PD.
Medical subject headings
- Cognition
- Executive Function
- Heterozygote
- Mutation
- Protein Serine-Threonine Kinases