Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy.
basic_science · Level V
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- Record sourced from PubMed, PMID 22915170.
- Also identified by DOI 10.1002/adma.201202433.
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Abstract
Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF(4):Yb,Er/NaGdF(4) core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.
Medical subject headings
- Lanthanoid Series Elements
- Metal Nanoparticles