Proteomic identification of a direct role for cyclin d1 in DNA damage repair.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22915759.
- Also identified by DOI 10.1158/0008-5472.CAN-11-3549 and PMC identifier 3432743.
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Abstract
The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair.
Medical subject headings
- Cyclin D1
- DNA Damage
- DNA Repair
- Proteomics