Aiding and abetting roles of NOX oxidases in cellular transformation.
review · Level V
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- Record sourced from PubMed, PMID 22918415.
- Also identified by DOI 10.1038/nrc3339 and PMC identifier 3711509.
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Abstract
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.
Medical subject headings
- Cell Transformation, Neoplastic
- NADPH Oxidases
- Neoplasms
- Reactive Oxygen Species