The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22921416.
- Also identified by DOI 10.1016/j.cmet.2012.06.016.
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Abstract
While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.
Medical subject headings
- Energy Metabolism
- Metabolic Diseases
- Metabolic Networks and Pathways
- Mitochondria
- Poly(ADP-ribose) Polymerases
- Transcription Factors