BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 22923459.
- Also identified by DOI 10.1136/thoraxjnl-2012-201971.
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Abstract
While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.
Medical subject headings
- BCG Vaccine
- HIV Infections
- Tuberculosis, Pulmonary