Unraveling stress-induced toxicity properties of graphene oxide and the underlying mechanism.

Zhang, Wendi; Wang, Chi; Li, Zhongjun; Lu, Zhenzhen; Li, Yiye; Yin, Jun-Jie; Zhou, Yu-Ting; Gao, Xingfa et al. · Adv Mater · 2012

basic_science · Level V

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Abstract

Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties.

Medical subject headings