One-pot synthesis of spheres-on-sphere silica particles from a single precursor for fast HPLC with low back pressure.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22936612.
- Also identified by DOI 10.1002/adma.201202810.
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Abstract
Spheres-on-sphere (SOS) silica particles are prepared in a one-pot scalable synthesis from mercaptopropyltrimethoxysilane with hydrophilic polymer and cationic surfactant under alkaline conditions. The SOS particles exhibit solid-core porous-shell properties. The fast separation of small molecules and proteins with low back pressure are demonstrated by high-performance liquid chromatography (HPLC) for the columns packed with SOS-particles.
Medical subject headings
- Chromatography, High Pressure Liquid
- Microspheres
- Proteins
- Silicon Dioxide