Mitochondrial fission, fusion, and stress.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 22936770.
- Also identified by DOI 10.1126/science.1219855 and PMC identifier 4762028.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by mixing the contents of partially damaged mitochondria as a form of complementation. Fission is needed to create new mitochondria, but it also contributes to quality control by enabling the removal of damaged mitochondria and can facilitate apoptosis during high levels of cellular stress. Disruptions in these processes affect normal development, and they have been implicated in neurodegenerative diseases, such as Parkinson's.
Medical subject headings
- Membrane Fusion
- Mitochondria
- Stress, Physiological