Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.
basic_science · Level V
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- Record sourced from PubMed, PMID 22936968.
- Also identified by DOI 10.1371/journal.pone.0035234 and PMC identifier PMC3003417.
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Abstract
The avian influenza (H5N1) viral RNA polymerase protein PA(C) was used as a target to screen nine chlorogenic acid derivatives for their polymerase inhibitor activity. Among them, seven compounds were PA(C) ligands, and four inhibited influenza RNA polymerase activity. These results aid in the design of anti-influenza agents based on caffeoylquinic acid.