Singles engage the RNA interference pathway.
basic_science · Level V
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- Record sourced from PubMed, PMID 22939614.
- Also identified by DOI 10.1016/j.cell.2012.08.008.
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Abstract
Single-stranded RNAs interact with components of the RNA interference pathway to reduce the expression of target mRNAs. Now, Lima et al. and Yu et al. show that, with extensive chemical modifications, small single-stranded RNAs can robustly induce gene silencing with efficacy similar to their double-stranded counterparts.