Holding on through DNA replication: histone modification or modifier?
editorial · Level V
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- Record sourced from PubMed, PMID 22939615.
- Also identified by DOI 10.1016/j.cell.2012.08.006.
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Abstract
Histone methylation is widely believed to contribute to epigenetic inheritance by persevering through DNA replication and subsequently templating methylation of daughter chromosome regions. However, a report in this issue (Petruk et al.) suggests that chromatin association of the methytransferase complexes themselves persists through replication and re-establishes histone methylation.