LIS1 clamps dynein to the microtubule.
basic_science · Level V
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- Record sourced from PubMed, PMID 22939616.
- Also identified by DOI 10.1016/j.cell.2012.08.010.
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Abstract
Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic dynein.