Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22941789.
- Also identified by DOI 10.1002/adma.201201484 and PMC identifier 3626403.
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Abstract
Thrombosis, or malignant blood clotting, is associated with numerous cardiovascular diseases and cancers. A microbubble contrast agent is presented that produces ultrasound harmonic signal only when exposed to elevated thrombin levels. Initially silent microbubbles are activated in the presence of both thrombin-spiked and freshly clotting blood in three minutes with detection limits of 20 nM thrombin and 2 aM microbubbles.
Medical subject headings
- Aptamers, Nucleotide
- Blood
- Blood Coagulation
- Microbubbles
- Molecular Imaging
- Thrombin
- Ultrasonography