Alpha-globin gene markers identify genetic differences between Australian aborigines and Melanesians.
basic_science · Level V
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- Record sourced from PubMed, PMID 2294746.
- Also identified by PMC identifier 1683541.
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Abstract
Australian aborigines exhibit a number of alpha-globin cluster rearrangements involving both alpha- and zeta-globin genes. alpha+-Thalassemia (-alpha/) in this population is heterogeneous and includes the 3.7 types I, II, and III gene deletions. The alpha alpha alpha/ and zeta zeta zeta/ rearrangements are each found in association with two haplotypes, indicating origins from at least two separate DNA crossover events. Differences in alpha-globin cluster rearrangements and in haplotypes between Australian aborigines, Papua New Guinea highlanders and island Melanesians, are consistent with multiple colonizing events into Australia.
Medical subject headings
- Black People
- Gene Rearrangement
- Genetics, Population
- Globins
- Multigene Family