A radical view of pathological vasculature.
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- Record sourced from PubMed, PMID 22958916.
- Also identified by DOI 10.1016/j.cmet.2012.08.008.
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Abstract
Striking results reported by Okuno et al. (2012) in the July issue of Nature Medicine show that the ataxia telangiectasia mutated (ATM) kinase counteracts excessive oxygen radical production in immature angiogenic blood vessels. Its deletion results in activation of the mitogen-activated protein kinase p38α and arrest of pathological angiogenesis.