Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 22958927.
- Also identified by DOI 10.1016/j.stem.2012.08.003 and PMC identifier 3466808.
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Abstract
In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
Medical subject headings
- Cellular Senescence
- Cytoprotection
- Epithelial Cells
- Mucositis
- Radiation Injuries
- Stem Cells
- TOR Serine-Threonine Kinases