Label-free polypeptide-based enzyme detection using a graphene-nanoparticle hybrid sensor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22961629.
- Also identified by DOI 10.1002/adma.201202961 and PMC identifier 3626444.
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Abstract
A graphene-nanoparticle (NP) hybrid biosensor that utilizes an electrical hysteresis change to detect the enzymatic activity and concentration of Carboxypeptidase B was developed. The results indicate that the novel graphene-NP hybrid biosensor, utilizing electrical hysteresis, has the ability to detect concentrations of targeted enzyme on the micromolar scale. Furthermore, to the knowledge of the authors, this is the first demonstration of a graphene-based biosensor that utilizes a hysteresis change resulting from metallic NPs assembled on a graphene surface.
Medical subject headings
- Biosensing Techniques
- Carboxypeptidase B
- Conductometry
- Graphite
- Nanoparticles
- Peptides