Bacteria-responsive multifunctional nanogel for targeted antibiotic delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22961974.
- Also identified by DOI 10.1002/adma.201202847.
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Abstract
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger antibiotic release by degrading the polyphosphoester core. The mannosylated nanogel preferentially delivers drugs to macrophages and leads to drug accumulation at bacterial infection sites through macrophage transport. This nanogel provides macrophage targeting and lesion site-activatable drug release properties, which enhances bacterial growth inhibition.
Medical subject headings
- Anti-Bacterial Agents
- Bacteria
- Drug Carriers
- Polyethylene Glycols
- Polyethyleneimine