Extrapolating from animals to humans.

Ioannidis, John P A · Sci Transl Med · 2012

expert_opinion · Level V

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Abstract

Because of a variety of caveats, the safety and effectiveness of interventions in human subjects can only be speculated from animal studies. Careful synthesis of data from multiple animal studies is needed to begin to assess the likelihood of successful cross-species translation (Fay et al., this issue).

Medical subject headings