The effect of photochemotherapy with 4,4',6 trimethylangelicin on murine cutaneous immune cells.
basic_science · Level V
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Abstract
The effect of photochemotherapy with 4,4',6 trimethylangelicin (TMA), a new monofunctional furocoumarin with a high antiproliferative activity, was studied on murine dendritic epidermal cells. Female mice (C3H/HeN[MTV-]) were treated topically with the drug three times a week for 4 consecutive weeks followed each time by 1 J/cm2 of UVA radiation. At the end of the treatment almost total depletion of ATPase+, Ia+ and Thy-1+ dendritic epidermal cells was observed, associated with marked hyperpigmentation but no gross or microscopic phototoxicity. Although 4,4',6 TMA is not phototoxic in mice, it affects the cutaneous immune cells.
Medical subject headings
- Dendritic Cells
- Furocoumarins
- Photochemotherapy
- Skin