Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22975994.
- Also identified by DOI 10.1038/ki.2012.163.
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Abstract
Chronic kidney disease (CKD) is characterized by progressive decline in renal function. Podocyte dropouts contribute to the pathogenesis of diabetic and nondiabetic CKD. Zhou and colleagues demonstrate that the association between advanced oxidation protein products (AOPPs) and receptor for advanced glycation end products (RAGE) elicited podocyte injuries, using cultured podocytes and mice injected with AOPPs. This study suggests that the blockade of RAGE is preventive and therapeutic against podocyte apoptosis caused by oxidative stress-related AOPPs in CKD.
Medical subject headings
- Advanced Oxidation Protein Products
- Apoptosis
- Podocytes
- Receptors, Immunologic
- Renal Insufficiency, Chronic