The mitochondrial SIRT1-PGC-1α axis in podocyte injury.
Level V
Where this comes from
- Record sourced from PubMed, PMID 22975995.
- Also identified by DOI 10.1038/ki.2012.182.
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Abstract
Dysfunction of mitochondria in podocytes is believed to be a trigger of injury and contributes to progressive glomerular sclerosis; however, the mechanisms had not been fully understood. Yuan et al. report involvement of SIRT1 (a homolog of the life-extending gene sir2 in mammals) and PPAR-γ coactivator 1α, a major regulator of oxidative metabolism, in mitochondria during podocyte injury. This information will be important in exploration of the mechanisms and future treatment of glomerular sclerosis.
Medical subject headings
- Aldosterone
- Apoptosis
- Kidney Diseases
- Mitochondria
- Podocytes
- Trans-Activators