Progress in targeted therapy against human immunodeficiency virus [corrected].

Abstract

Acquired immunodeficiency syndrome (AIDS) and its related disorders are caused by a retrovirus termed human immunodeficiency virus (HIV). HIV has nine known genes, and each gene provides a target of opportunity for a therapeutic intervention. Knowledge of the life cycle of this virus has already yielded clinically useful therapies and will likely make a major impact against AIDS in the near future, provided that the principles of controlled trials are followed.