Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 22984114.
- Also identified by DOI 10.1093/infdis/jis588.
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Abstract
A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.
Medical subject headings
- Asian People
- Crohn Disease
- Leprosy