Efficacy and safety of rituximab treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitides: results from a German registry (GRAID).
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 22984269.
- Also identified by DOI 10.3899/jrheum.120482.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Rituximab (RTX) therapy is a treatment option in patients with refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We investigated the tolerability and clinical efficacy of RTX in a cohort of patients with refractory AAV. Clinical and safety data of patients with AAV treated with RTX were retrospectively assessed from the data of a German national registry. In total, 58 patients were included in this analysis (50/58 with granulomatosis with polyangiitis; 8/58 with microscopic polyangiitis who received at least 1 cycle, 17 patients who received 2 cycles, and 3 patients who received 3 cycles of RTX). Response was classified as complete and partial in 22 (40%) and in 29 cases (52.7%), respectively. Four patients (7.3%) were classified as nonresponders. RTX was well tolerated with good clinical efficacy in patients with refractory AAV.
Medical subject headings
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
- Antibodies, Monoclonal, Murine-Derived
- Registries