Nanostructured thin film polymer devices for constant-rate protein delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22985294.
- Also identified by DOI 10.1021/nl302747y and PMC identifier 3480309.
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Abstract
Herein long-term delivery of proteins from biodegradable thin film devices is demonstrated, where a nanostructured polymer membrane controls release. Protein was sealed between two poly(caprolactone) films, which generated the thin film devices. Protein release for 210 days was shown in vitro, and stable activity was established through 70 days with a model protein. These thin film devices present a promising delivery platform for biologic therapeutics, particularly for application in constrained spaces.
Medical subject headings
- Drug Delivery Systems
- Nanostructures
- Proteins