Complex stiffness gradient substrates for studying mechanotactic cell migration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22991224.
- Also identified by DOI 10.1002/adma.201202520.
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Abstract
Polyacrylamide gels are cast upon a stiff support with controlled topography, resulting in a thin gel layer of variable height. The topographical profiles project a stiffness map onto the gel, resulting in controlled linear and non-linear 2D stiffness gradients. Fibroblasts, which migrate towards stiffer substrates, accumulate in areas with a gel thickness below 15 μm.
Medical subject headings
- Acrylic Resins
- Cell Movement
- Mechanotransduction, Cellular