Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23001882.
- Also identified by DOI 10.1002/adma.201201742.
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Abstract
Coordination polymer coated mesoporous silica nanoparticles for drug delivery are successfully synthesized. The system ensures that drugs are stored in the mesopores under a physiological environment. Upon H(+) stimulus in the endosomal and lysosomal compartments, the drugs are released into the intracellular organelles of cancer cells, effectively killing the cells.
Medical subject headings
- Drug Delivery Systems
- Nanoparticles
- Polymers
- Silicon Dioxide
- Topotecan