Multicompartment intracellular self-expanding nanogel for targeted delivery of drug cocktail.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23001909.
- Also identified by DOI 10.1002/adma.201202687.
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Abstract
A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.
Medical subject headings
- Antineoplastic Agents
- Doxorubicin
- Drug Delivery Systems
- Paclitaxel
- Polyethylene Glycols
- Polyethyleneimine