Defending the cornea with antibacterial fragments of keratin.
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- Record sourced from PubMed, PMID 23006322.
- Also identified by DOI 10.1172/JCI65380 and PMC identifier 3461931.
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Abstract
In addition to its role in refraction, the cornea forms a barrier between the eye and environmental and infectious insults. Corneal infections are surprisingly rare, suggesting that multiple aspects of the immune system are at play in mediating protection. In this issue of the JCI, Tam et al. describe the unexpected role of a structural protein, cytokeratin 6A, in this process.