Use of reprogrammed cells to identify therapy for respiratory papillomatosis.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 23013073.
- Also identified by PMC identifier 4030597.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. The increased size of the latter viral genome was due to duplication of the promoter and oncogene regions. Chemosensitivity testing identified vorinostat as a potential therapeutic agent. At 3 months after treatment initiation, tumor sizes had stabilized, with durable effects at 15 months.
Medical subject headings
- Antineoplastic Agents
- Hydroxamic Acids
- Lung
- Lung Neoplasms
- Papillomavirus Infections
- Respiratory Tract Infections