Antimicrobial and antifouling hydrogels formed in situ from polycarbonate and poly(ethylene glycol) via Michael addition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23018988.
- Also identified by DOI 10.1002/adma.201202225.
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Abstract
A novel class of antimicrobial cationic polycarbonate/PEG hydrogels are designed and synthesized by Michael addition chemistry. These hydrogels demonstrate strong broad-spectrum antimicrobial activities against various clinically isolated multidrug-resistant microbes. Moreover, they exhibit nonfouling properties and prevent the substrate from microbial adhesion. These antimicrobial and antifouling gels are promising materials as catheter coatings and wound dressings to prevent infections.
Medical subject headings
- Anti-Bacterial Agents
- Biofouling
- Hydrogels
- Polycarboxylate Cement
- Polyethylene Glycols